Oil of citronella is a naturally occurring insect and animal repellent distilled from two grass varieties. It is yellow to brown and has a grassy/floral smell. Oil of citronella is a mixture of many components. The exact composition varies by grass variety. However, the main components are citronellol, citronellal, and geraniol. Oil of citronella is also commonly found in foods and beverages as a flavoring agent. It is Generally Recognized as Safe (GRAS) as a food additive by the Food and Drug Administration.

Oil of citronella was first registered in the United States in 1948. It is currently on the U.S. Environmental Protection Agency's (U.S. EPA) list of minimum risk pesticides.

Currently oil of citronella can be found in over a dozen registered pesticide products. Some of these products are applied to animal or human skin, ornamental plants, or other outdoor areas. Oil of citronella can be formulated into sprays, lotions, candles, pellets, and pouches. It can also be found in some sunscreen products, wristbands, and flea collars.

Oil of citronella repels target pests rather than killing them. It works by masking scents that are attractive to insects. Thus, insects find it difficult to locate their target to feed. Oil of citronella may also work by masking odors attractive to animals. However, no studies could be located.

People can be exposed to chemicals if they eat, breathe, or get them on their skin or in their eyes. People are most commonly exposed to oil of citronella by breathing in vapors or by applying spray-on repellents to their skin. People may also be exposed if they inhale the spray mist or fail to wash their hands before eating or smoking. However, exposure can be limited by following the label instructions.

Citronellol, citronellal, and geraniol are the major components of oil of citronella. If eaten, they are broken down and leave the body through the urine.

The potential of oil of citronella to cause cancer has not been studied. However, studies have shown that oil of citronella does not alter or damage genes. Geraniol, a major component of oil of citronella, has been observed in several studies to reduce the growth of some cancers. In another study, large doses of some minor components of oil of citronella were fed to rodents five times per week for two years. There was no evidence of increased cancer rates. However, methyleugenol, a minor component of oil of citronella, is “reasonably anticipated to be a human carcinogen” by the U.S. Department of Health and Human Services. It has caused the development of tumors in mice.

Citronellol and geraniol are major components of oil of citronella. In one study, small doses of citronellol were fed to rats daily for 12 weeks. No adverse effects were observed. In another set of studies rats were fed small and moderate doses of geraniol for several months. No adverse effects were observed.

In general, children may be especially sensitive to pesticides. If applied to the skin, oil of citronella can cause skin irritation or allergic reactions in some people. Therefore, some oil of citronella products should not be used on children less than six months old unless directed by a doctor. This information is listed on the product label.

Additionally, unintended exposures can be minimized by following common sense tips. Do not allow children to apply the repellent themselves. Young children may put their hands in their mouths. Consider avoiding their hands, in addition to their eyes and mouth, while applying the repellent. Also, more control can be achieved by first applying the repellent to your hands and then using your hands to apply it on the child.

Oil of citronella is practically non-toxic to birds. It is slightly toxic to fish and other aquatic organisms. Oil of citronella repels insects rather than killing them. Therefore, bees and other pollinators are not likely to be harmed. Oil of citronella is unlikely to affect birds, fish or other wildlife in a harmful way because of its low toxicity and use patterns.